Police said the 16-year-old was trapped under the vehicle after it crashed into O'Reilly and Daly Chemist on Railway Parade just before 11.30am. She suffered critical injuries and died at the scene.

Superintendent Dave Donohue said the girl was waiting for a bus at the bus stop when she was hit by the Mitsubishi Challenger four-wheel-drive just before 11.30am.

The car, being driven by a woman with a passenger and two young children on board, then crashed into the front of the chemist.

Superintendent Donohue said the incident occurred in the ‘‘exact same spot’’ as a fatal crash in 2007.

He said the driver had not been interviewed but police were investigating whether speed was a factor.

The driver was taken to St George Hospital suffering from shock. Police said she would undergo mandatory blood and urine testing.

A female employee of the pharmacy and a male customer were also injured, police said. They were taken to St George Hospital for treatment.

Car slams into chemist in Sydney suburb of Kogarah pic.twitter.com/Cwkl7SFw9x — Martin Andrew Zavan (@zavanos) September 15, 2014

A NSW Police spokeswoman said officers were at the scene, near the intersection with Montgomery Street.

However, she said the circumstances of the crash were not known.

The pharmacy is on a corner and is directly across from Kogarah railway station.

The white four-wheel-drive was wedged in the front of the shop, with shattered glass and debris spread across the footpath.

"It could have been a lot worse,’’ Superintendent Donohue said.

‘‘There was a lot of people at the bus stop.

‘‘Certainly it’s a busy area with people coming and going from the train station.’’

He said it appeared the driver was turning left from Montgomery Street into Railway Parade.

Megan Barker, the president of the Kogarah Chamber of Commerce, described the intersection where the crash occurred as extremely confusing for drivers.

"This is a repeat of seven years ago, when a car lost control and hit the bus stop," she said.

"For one, we need signage so that cars coming around Railway Parade north know they have to give way to traffic coming down Montgomery Street, that they have to put on their right blinker. There's no signage, nobody knows that," she said.

"We need proper signage, we need bollards up so that this will never happen again. We also need that bus stop removed. It's right on that bend and it's a blind spot. It was an accident waiting to happen."

In the 2007 accident, fashion student Emma Hansen, 20, died and 11 were injured when a learner driver at the wheel of the Toyota Echo crashed into a queue waiting for a bus.

The 2008 inquest into Ms Hansen's death heard the driver panicked when her instructor put his hands on the wheel as she took a corner too widely, and she placed her foot on the accelerator rather than the brake.