Kurri Kurri and Cessnock have both named key players under injury spotlight for their a top-five showdown at Kurri Kurri Sportsground on Saturday.
The Bulldogs have named Newcastle and NSW Pioneers representative Mitch Cullen after he underwent scans this week on a suspected broken foot.
"We're not quite sure [of the damage] yet, we're hoping it's just deep bruising but it could be a broken foot," Griffith said of Cullen's injury.
"It would be devastating for us to lose him because we are already struggling a bit around the middle."
The Bulldogs will be without prop Jordan Mitchell, who picked up a hamstring injury in his first carry last start and looks set for a six-to-seven week stint on the sidelines.
"That's definitely a long-term one," Griffiths said.
Kurri playmaker Jade Porter (knee) resumed "full sprinting" at training on Tuesday but Griffiths doesn't expect the experienced campaigner back until July 7.
Cessnock has named all three players under injury clouds to play.
Harry O'Brien (shoulder) and Josh Charles (hand) were both rated a "50-50" chance of playing by coach Todd Edwards.
Marvin Filipo (hamstring) has been named in the team but it would be no surprise if he was a late withdrawal.