The 12 sequestered jurors were expected to consider three weeks of testimony from 45 witnesses, including bystanders and medical experts, along with hours of video evidence that make up the most high-profile US police misconduct case in decades.

Chauvin, who is white, has pleaded not guilty to second-degree unintentional murder, third-degree "depraved mind" murder and second-degree manslaughter.

After listening to closing arguments for most of Monday, the jury must reach a unanimous verdict on each charge to convict or acquit. A single hold-out would result in a mistrial, although the state could then try Chauvin again.

Chauvin pushed his knee into the neck of Floyd, a 46-year-old handcuffed black man, for more than nine minutes outside the grocery store where Floyd had been accused of buying cigarettes with a fake $US20 bill.

The case hinges on whether the jury believes the prosecution argument that Chauvin used excessive, and therefore illegal, force that killed Floyd.

The defence has countered that Chauvin behaved as any "reasonable police officer" would," and sought to raise doubts about the cause of Floyd's death, saying heart disease or even the exhaust fumes from the nearby police car may have been factors.

The jury is comprised of four white women, two white men, three black men, one black woman and two multiracial women, according to court records.

The court has promised to shield their identities until some time after they give their verdict.

Australian Associated Press